Post-doc position "Functionalized nanoliposome as new generation of drug delivery for cancer therapy"
DESCRIPTION
Functionalized nanoliposome as new generation of drug delivery for cancer therapy
These last decades our research on active nanoliposome as a drug delivery system combined with curcumin has shown promising results on in vitro viability of cancer cell lines (MCF7) for cancer therapy. Moreover, previous researches showed that hydrazinocurcumin (a synthetic analogue of curcumin) is able to re-educate pro-tumor (M2) macrophages into anti-tumor (M1) macrophages, leading to reduced tumor growth, angiogenesis and invasion. Indeed, it is known that a high M1 to M2 ratio is significantly correlated with extended overall survival of non-small cell lung cancer (NSCLC). Therefore, the goal of our project is to fabricate a new generation of drug delivery based on nanoliposome co-encapsulating curcumin and doxorubicin, which is a common chemotherapeutic drug used in cancer therapy, for lung cancer therapy by inducing an effective immune-modulating treatment for NSCLC.
Skills : In order to realize this project, the candidate should master techniques such as AFM (Atomic Force Microscopy), targeting of nanoliposome and have knowledge on cancer cell culture biology.
This project is divided into several key steps:
- Designing nanoliposomes active rich on polyunsaturated fatty acids (PUFAs) obtained from by- products of fish containing doxorubicin and curcumin as their drug load
- Adding targeting moieties at nanoliposome to specifically target M2 tumor associated macrophages and lung cancer cells
- Studying in vitro the drug delivery efficacy and synergistic effect of dual anti-cancer drug delivery on NSCLC survival and polarize monocyte differentiation towards M1 phenotype not M2 tumor associate macrophage.
Scientific contacts:
Pr. Elmira Arab-Tehrany (LIBio) (Project manager)
TERMS AND TENURE
This position will be based at Laboratory of Biomolecular Engineering (LIBio) at University of Lorraine in collaboration with biological (CRAN, Biopôle), biophysical (LCPME) and chemical (LCPM, LRGP) laboratories. The duration cannot exceed 18 months.
The target start date for the position is March 2020, with some flexibility on the exact start date.
HOW TO APPLY
Applications are only accepted through email. All documents must be sent to the project manager
Deadline for application is 15th February 2020.
JOB LOCATION
Nancy, Lorraine, France
REQUIREMENTS
Applicants are requested to submit the following materials:
• A cover letter applying for the position
• Full CV, including academic records and list of publications
• Statement of Research
• Two Letters of recommendations