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LINDER Michel

LINDER Michel

  • Status : Professeur
  • Email address : michel.linder@univ-lorraine.fr
  • Speciality : Physicochemistry of lipids; nano-vectorisation
  • Phone number : +33 3 72 74 41 03
  • Fax number : +33 3 83 59 57 72

Activities :

Administrative activities

 

Professor at the University of Lorraine (Exceptional Class 2)- National School of Agronomy and Food Industries (E.N.S.A.I.A.) in Nancy

2018 - present: Expert at ANSES Working Group "Evaluation of Substances and Processes Submitted for Authorization in Human Food".

2018-2022: Head of the “Nutrition and Food Science” Program (NSA).

2018-2022: Head of the specialization "Food, Nutrition, Cosmetics" (ANC).

2016: Vice President of the 68th section of the National University Council (CNU).

2019-2023: President of the 68th section of the National University Council (CNU).

2016 - 2018: President of the French Society for the Study of Lipids.

2018 - present: Member of the French Society for the Study of Lipids.

Member of the European Federation for the Science and Technology of Lipid (EFL)

Member of the American Oil Chemists’ Society (AOCS)

2013-2017: Director of the Laboratory of Biomolecule Engineering (LIBio).

 

Ph.D. thesis at I.N.P.L. "Biotechnologies and Food Industries," 1996.

1999: 6 months at Dalhousie University's Canadian Institute of Fisheries Technology in Halifax, Nova Scotia, in a laboratory specialized in marine lipochemistry.

 

Recipient of the Chevreul Medal at the “Chevreul Days” 2023 celebrating the 80th anniversary of the French Society for the Study of Lipids (SFEL), held in Paris from January 18 to 20, 2023, in the Verniquet Amphitheater of the National Museum of Natural History, where Michel-Eugène Chevreul taught. The Chevreul Medal is awarded annually to a French or foreign personality who has significantly contributed to the development of knowledge or industrial achievements in the field of fatty substances. I presented part of my research activities on polar lipids of marine origin, from extraction through green processes to their use in nutraceuticals in the form of nanoliposomes.

Research activities

Understanding of the physicochemical mechanisms involved in the self-assembly processes of phospholipids at interfaces and the phenomena of encapsulation
and controlled release of biomolecules in the form of liposomes or nanoemulsions.

 

• Protein extraction through controlled enzymatic processes from meat, plant-based, or marine products.

• Study of the functional and nutritional properties of protein substrates.

• Fractionation of oils and fats on membrane supports. Understanding the interaction phenomena between hydrophobic compounds and filtering materials.

• Development of lipid fractions enriched in polyunsaturated fatty acids through enzymatic reactions combined with membrane filtration processes.

• Long-chain polyunsaturated fatty acids (DHA, EPA) and marine lecithin: vectorisation in the form of emulsion and nano-liposomes.

• Valorisation of used frying oils for non-food applications (biolubricants, mold release oils, etc.).

• Development of oleogels for food and non-food applications.

Optimization of industrial processes through experimental research methodology (design of experiments and mixtures).

 

                                                       

 

International Collaborations

• SAKURA Program initiated in 2011 (Hakodate, Japan): Collaboration with Professor Koretaro Takahashi's team at the "Marine Products and Food Science" laboratory at Hokkaido University.

• Department of Biomedical Engineering, University of California, Davis, USA: Nanovectorisation of active molecules and molecular transfers.

• Australian Nanoscience and Nanotechnology Initiative and Monash University LPO: Nanovectorisation; Liposomes.

• Institute of Technology, Department of Neuroscience and Brain Technology: Esters of DHA vectorization on phospholipids applied to neuronal cells.

 

Supervision

Supervision of 20 doctoral thesis, 30 DEA and Master’s students, and 15 post-doctoral researchers. Production of 150 international publications, including 120 A-ranked publications; 17 invited conferences; 55 international oral communications; 4 book chapters; 4 patents, and 2 ongoing exploitation licenses. Writing of 35 industrial contract reports, including 7 in the last 4 years. H index 50.

 

Publications 2018 - 2023

Ali H.H., Michaux F., Khanji A.N., Jasniewski J., and Linder M. 2018, Chitosan - Shea butter solid nanoparticles assemblies for the preparation of a novel nanoparticles in microparticles system containing curcumin. Colloids and Surfaces A: Physicochemical and Engineering Aspects 553,359-367.

Djikeng, FT, Womeni, HM, Anjaneyulu, E, Karuna MSL, Prasad, RBN, Linder, M. 2018. Effects of natural antioxidants extracted from Cameroonian ginger roots on the oxidative stability of refined palm olein- European Food Research and Technology.

Hasan, M., Latifi, S., Kahn, C., Tamayol, A., Habibey, R., Passeri, E., Linder, M., Arab-Tehrany, E. 2018. The positive role of curcumin-loaded salmon nanoliposomes on the culture of primary cortical neurons, Marine Drugs, 16 (7), 218.

Hasan, M., Elkhoury, K., Kahn, C.J.F., Arab-Tehrany, E, Linder, M. 2019. Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments, Molecules, 24(10), 2023-2028.

Malaplate, C., Poerio, A., Huguet, M., Soligot, C., Passerie, E., Kahn, C., Linder, M., Arab-Tehrany, E, Yen, F.T. 2019. Neurotrophic effect of fish-lecithin based nanoliposomes on cortical neurons, Marine Drugs, 17 (7), 406.

Vuillemin, ME Michaux, F Muniglia, L, Linder, M, Jasniewski J. 2019. Gum Arabic and chitosan self-assembly: Thermodynamic and mechanism aspects. Food Hydrocolloids, 96, 463-474.

Kadri, R., Bacharouch, J., Elkhoury, K., Ben Messaoud, G. Kahn, C. Desobry, S. Linder, M. Tamayol, A. Francius, G. Mano, J.F. Sánchez-González, L. Arab-Tehrany E. 2020. Role of active nanoliposomes on the surface and bulk mechanical properties of hydrogels. MTBIO (Received Date: 6 November 2019) https://doi.org/10.1016/j.mtbio.2020.100046

Bianchi, A., Velot, É., Kempf, H., Elkhoury, K., Sanchez-Gonzalez, L., Linder, M., Kahn, C. and Arab-Tehrany, E. 2020. Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes, International Journal of Molecular Sciences, 21(10): 3436. DOI: 10.3390/ijms21103436.

Mecheta, A., Hanachi, A., Jeandel, C., Arab-Tehrany, E., Bianchi, A., Velot, E., Mezali, K. and Linder, M. 2020. Physicochemical Properties and Liposomal Formulations of Hydrolysate Fractions of Four Sea Cucumbers (Holothuroidea: Echinodermata) from the Northwestern Algerian Coast, Molecules, 25(13): 2972. DOI:  10.3390/molecules25132972.

Arab-Tehrany, E., Elkhoury, K., Francius, G., Jierry, L., Mano, J., Kahn, C. and Linder, M. 2020. Curcumin Loaded Nanoliposomes Localization by Nanoscale Characterization, International Journal of Molecular Sciences, 21(19): 7276. DOI: 10.3390/ijms21197276

Kuznetcova, D., Linder, M., Jeandel, C., Paris, C., Desor, F., Baranenko, D., Nadtochii, L., Arab-Tehrany, E. and T. Yen, F. 2020. Nanoliposomes and Nanoemulsions Based on Chia Seed Lipids: Preparation and Characterization, International Journal of Molecular Sciences, 21(23): 9079. DOI: 10.3390/ijms21239079.

Kadri., R., Bacharouch, J., Elkoury, K., Ben Messaoud G., Kahn, C., Desobry, S., Linder, M., Tamayol, A., Francius G., Sanchez-Gonzales, L., Arab Tehrany, E. and Mano, J.F. 2020. Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels, Materials Today Bio, 6, 100046. DOI: 10.1016/j.mtbio.2020.100046.

Hasan, M., Elkhoury, K., Belhaj, N., Kahn, C., Tamayol, A., Barberi-Heyob, M., Arab-Tehrany, E. and Linder, M. 2020. Growth-inhibitory effect of chitosan-coated liposomes encapsulating curcumin on MCF-7 breast cancer cells, Marine drugs, 18(4): 217. DOI: 10.3390/md18040217.

Li, J., Elkhoury, K., Barbieux, C., Linder, M., Grandemange, S., Tamayol, A., Francius, G., Arab-Tehrany, E. 2020. Effects of bioactive marine-derived liposomes on two human breast cancer cell lines, Marine drugs, 18(4): 211. DOI: 10.3390/md18040211.

Vuillemin, M., Michaux F., Adam, A., Linder, M., Muniglia, L., Jasniewski, J. 2020. Physicochemical characterizations of gum Arabic modified with oxidation products of ferulic acid, Food Hydrocolloids, 107: 105919. DOI:  10.1016/j.foodhyd.2020.105919.

Konishi, K., Du, L., Francius, G., Linder, M., Sugawara, T., Kurihara, H. and Takahashi, K. 2020. Lipid Composition of Liposomal Membrane Largely Affects Its Transport and Uptake through Small Intestinal Epithelial Cell Models, Lipids, 55(6): 671-682. DOI: 10.1002/lipd.12269.

Passeri, E., Elkhoury, K., Jiménez Garavito, M.C., Desor, F., Huguet, M., Soligot-Hognon, C., Linder, M., Malaplate, C., Yen, F. and Arab-Tehrany, E. 2021. Use of Active Salmon-Lecithin Nanoliposomes to Increase Polyunsaturated Fatty Acid Bioavailability in Cortical Neurons and Mice, International Journal of Molecular Sciences, 22(21):11859. DOI : 10.3390/ijms222111859.

Vuillemin, M., Muniglia, L., Linder, M., Bouguet-Bonnet, S., Poinsignon, S., Dos Santos Morais, R., Simard, B., Paris, C., Michaux, F. and Jasniewski, J. 2021. Polymer functionalization through an enzymatic process: Intermediate products characterization and their grafting onto gum Arabic, International Journal of Biological Macromolecules, 169:480–491. DOI : 10.1016/j.ijbiomac.2020.12.113.

Ait Chekdid A., Kahn C.J.F., Prévot E., Ferrières M., Lemois B., Choquet C., Linder M. 2021. Mixture design applied for formulation and characterization of vegetal-based fermented products, LWT-Food Science and Technology, 111336. DOI: 10.1016/j.lwt.2021.111336.

Bennacef, C., Desobry-Banon, S., Linder, M., Khanji, A., Probst, L. and Desobry, S. 2021. Study and optimization of core-shell capsules produced by annular jet breaking coextrusion, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 629:127475. DOI: 10.1016/j.colsurfa.2021.127475.

Vuillemin M, Michaux, F., Seiler, A., Linder, M., Muniglia, L., Jasniewski, J. 2022. Polysaccharides enzymatic modification to control the coacervation or the aggregation behavior: a thermodynamic study. Food Hydrocolloids 122, 107092

Velot, E., Elkhoury, K., Kahn, C., Kempf, H., Linder, M., Arab-Tehrany, E., Bianchi, A. 2022. Efficient TGF-β1 Delivery to Articular Chondrocytes In Vitro Using Agro-Based Liposomes. International Journal of Molecular Sciences 23 (5), 2864

Hanachi, A., Bianchi, A., Kahn C. JF, Velot, E., Arab-Tehrany, E., Cakir-Kiefer, C., Linder, M. 2022. Encapsulation of Salmon Peptides in Marine Liposomes: Physico-Chemical Properties, Antiradical Activities and Biocompatibility Assays. Marine Drugs. 20, 4, 249.

Tonfack Djikeng, F., Macaire Womeni, H., Sri Lakshmi Karuna, M., Tiencheu, B., Ufuan Achidi, A., Linder,M., Badari Narayana Prasad, R. 2022. Preservative Effect of Ginger Root (Zingiber officinale R.) Extract in Refined Palm Olein Subjected to Accelerated Thermal Oxidation. Journal of Food Quality Vol 2022, Article ID 388201, https://doi.org/10.1155/2022/338820.

Passeri, E., Bun, P., Elkhoury, K., Linder,M.,  Malaplate, C., T. Yen, F., Arab-Tehrany, E. 2022. Transfer Phenomena of Nanoliposomes by Live Imaging of Primary Cultures of Cortical Neurons. Pharmaceutics, 14, 2172. https://doi.org/10.3390/pharmaceutics14102172

Velot, E., Ducrocq, F., Girardeau, L., Hehn, A., Piutti, S., Kahn, C., Linder, M., Bianchi, A., Arab-Tehrany, E. 2022. Hop Extract Anti-Inflammatory Effect on Human Chondrocytes Is Potentiated When Encapsulated in Rapeseed Lecithin Nanoliposomes. Int. J. Mol. Sci., 23, 12423. https://doi.org/10.3390/ijms232012423.

Passeri , Ka, E., Elkhoury,  K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., T. Yen, F., Arab-Tehrany, E. 2022. Alzheimer’s Disease: Treatment Strategies and Their Limitations Int. J. Mol. Sci. 2022, 23, 13954. https://doi.org/10.3390/ijms232213954.

Peyret, C., Elkhoury, K., Bouguet-Bonnet, S., Poinsignon, S., Boulogne, C., Giraud, T., Stefan, L., Tahri, Y., Sanchez-Gonzalez, L., Linder, M., Tamayol, A., Kahn, C. J.F., Arab-Tehrany, E. 2023. Gelatin Methacryloyl (GelMA) hydrogel scaffolds: predicting physical properties using an experimental design approach. International Journal of Molecular Sciences 24 (17), 13359.

Ait Chekdid, A., Kahn, J. F., Lemois, B., Linder, M. 2023. Impact of a Starch Hydrolysate on the Production of Exopolysaccharides in a Fermented Plant-Based Dessert Formulation. Foods, 12(20), 3868; https://doi.org/10.3390/foods12203868.

Ben Mihoub, A., Elkhoury, K., Nel, J., Acherar, S., Velot, E., Malaplate, C., Linder, M.,  Latifi, S., Kahn, C.J.F., Huguet, M., T Yen, F., Arab-Tehrany, E. 2023. Neuroprotective Effect of Curcumin-Loaded RGD Peptide-PEGylated Nanoliposomes. Pharmaceutics, Vol 15 (12), 2665.

 

Teaching

Head of the Master's in Biotechnological and Food Process Sciences (SPBA).

Teaching in Master 1, Master 2, and during the 3 years of Engineering at ENSAIA.

Head of the Nutrition and Food Sciences Program (NSA).

Head of the specialization "Food, Nutrition, Cosmetics" (ANC).

 

Fundamental and applied scientific training aimed at training researchers and scientific executives in the fields of Biotechnological and Food Processes, Food Sciences, as well as disciplines related to nutrition and food safety.

Topics covered include:

- Dairy fat and its transformation

- Functionalities of oils and fats

- Food emulsions: structures and properties

- Design of experiments and mixtures with and without constraints (Response surface methodology; NemrodW)

- Quality Management - Risks and Management of Food Crises.